Modeling approaches for qualitative and semi-quantitative analysis of cellular signaling networks
نویسندگان
چکیده
منابع مشابه
Qualitative and Quantitative Approaches for Determination of Hemolyzed Serum
Abstract Background and Objective: Prevention of medical laboratory errors is a major goal of quality control programs. Hemolyzed specimen is one of the common issues causing medical laboratory errors. Apart from the visual assessment, the measurement of serum hemoglobin concentration can be another method to evaluate the intensity of hemolysis. We aimed to assess hemolyzed serum s...
متن کاملComputational approaches for modeling regulatory cellular networks.
Cellular components interact with each other to form networks that process information and evoke biological responses. A deep understanding of the behavior of these networks requires the development and analysis of mathematical models. In this article, different types of mathematical representations for modeling signaling networks are described, and the advantages and disadvantages of each type...
متن کاملQuantitative proteomic analysis of phosphotyrosine-mediated cellular signaling networks.
Receptor tyrosine kinases receive extracellular cues, such as ligand binding, and transmit this information to the cell through both autophosphorylation and phosphorylation of tyrosine residues on selected substrates, stimulating a variety of signal transduction pathways. Quantitative features, including intensity, timing, and duration of phosphorylation of particular residues, may play a role ...
متن کاملGroundwater Modeling: Semi-Analytical Approaches for Heterogeneity and Reaction Networks
Reactive transport modeling for heterogeneous aquifers is challenging and computationally intensive. While numerical packages allow simulation of multiple species transport with aquifer heterogeneity, run times on high speed PCs and workstations make many jobs impractical. Stream tube approaches are computationally efficient numerical methods, and offer significant advantages in run time over m...
متن کاملThe Database of Quantitative Cellular Signaling: management and analysis of chemical kinetic models of signaling networks
MOTIVATION Analysis of cellular signaling interactions is expected to pose an enormous informatics challenge, perhaps even larger than analyzing the genome. The complex networks arising from signaling processes are traditionally represented as block diagrams. A key step in the evolution toward a more quantitative understanding of signaling is to explicitly specify the kinetics of all chemical r...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Cell Communication and Signaling
سال: 2013
ISSN: 1478-811X
DOI: 10.1186/1478-811x-11-43